NEXCOPE NCF1000

CONFOCAL MICROSCOPE

NCF1000 Super Vision , Super Resolution , Super Speed

• NCF1000 Confocal Laser Microscope – Built for High-Efficiency Imaging. in life science research, the need for in-depth analysis of tissues, organs, and biological models continues to grow. This makes broader imaging coverage and shorter acquisition times essential for accurate intracellular observations.The NCF1000 is a high-performance confocal laser microscope designed to meet these advanced requirements. With its wide scanning capacity and optimized imaging speed, it delivers the high-quality data today’s biological research demands—reliably and efficiently.

 

• The NCF1000 Confocal Laser Microscope is equipped with a best-in-class 25 mm field of view, allowing seamless imaging across large sample areas without limitations. With a scan resolution of 8192 × 8192 pixels, it delivers vivid, high-fidelity images—even when using low magnification objectives. Designed for performance, the system supports high-speed imaging up to 60 fps (at 8×256 pixels), combining a wide field of view with exceptional resolution in each frame. This enables researchers to collect more data, faster, without compromising image quality.

 

• A wider field of view, higher resolution, and faster scanning deliver sharper images, richer contrast, and more lifelike colors. This empowers you to explore the nanoscale world within the cell, interpret cellular responses with greater clarity and intuition, and push the boundaries of your research—constantly unlocking new frontiers in life sciences.

NCF1000 – A New Era in Scientific Imaging

The product of ten years of innovation and engineering, the NCF1000 confocal laser microscope is a next-generation solution built upon the NCF930 and NCF950 models.

This advanced system offers major breakthroughs in optical structure, resolution and imaging speed, while also featuring deep optimizations in intelligent control and electrical design. As a result, complex experimental processes are now much more intuitive, faster and more efficient.

The NCF1000 is designed to turn your scientific goals into reality and support you on your journey to discover the unknown.

Large high-resolution images combined with fewer thumbnails

Used in conjunction with the NIB1000 inverted microscope, the NCF1000 can produce high-quality confocal images with a 25 mm field of view (FOV). The wide field of view reduces the number of images and image acquisition time required to stitch large images. It also provides uniform brightness, high efficiency, and high throughput on large samples.

Get More Data from Every Sample

Equipped with an industry-leading 25 mm field of view, the NCF1000 confocal microscope can capture images of large samples in a single scan, delivering 1.5x higher throughput than previous-generation microscopes. It can combine scan sizes of up to 8192×8192 pixels to meet the increasing demand for analyzing tissues, organs, and live + model organisms for vital biological data in life science research.

NIS Apochromat TIRF 100X Oil 100X APOTIRF

With unparalleled high resolution and a numerical aperture (NA) of 1.49, it is the ultimate lens of the NIS series. Spherical aberrations generated at different viewing temperatures (23°C and 37°C) can be optimized.

NIS Apochromat 20X C WI 20X APO Water

To minimize spherical aberration and light loss due to refractive differences, observe the optimum image of cells and other samples in culture medium that is close to the refractive indices of the culture cells and culture medium.

NIS Plan Apochromat Series

The highest professional-grade objective lens also reaches new limits in numerical aperture and working distance, providing excellent aberration correction across the entire field of view, providing image quality unattainable with conventional lenses.

Efficient Scanner and Detector

NCF1000 uses a high-precision scanning galvanometer system and a stepped electric pinhole integrated inside the scanning head to achieve low noise, high contrast and high-quality confocal imaging. The scanning size of 8192x8192 pixels can break through the limitation of the optical line, even if low-magnification objectives are used, achieve excellent high-precision, degree of sampling, capture and archive microscopic details.

Faster Scanning

Real-time four-channel synchronous imaging High-speed imaging capability of up to 60 fps (8*256 pixels) reduces the sample exposure time at high light intensity and significantly reduces high toxicity. High-speed imaging can realize high-frequency data acquisition, which can capture the dynamic phenomena and long-term change process of the sample, and accurately record in real time. Analysis to meet the complex and demanding imaging needs of life sciences.

Real Time Four Channel Synchronous Imaging

NCF1000 confocal microscope uses the most advanced four-channel fluorescence fusion technology, allowing researchers to precisely analyze, observe and image multiple channels in real time. It simultaneously detects and analyzes four different fluorescent markers in the same field of view, seamlessly fuses multiple signals, and cooperates with high-precision spectral resolution imaging. This clearly reveals multi-level and multi-dimensional complex information within the sample, greatly improving experiment speed and data accuracy.

Flexible and Powerful Software NOMIS PRO X-C

High speed hardware control

It offers users unprecedented ease of control. You can easily digitally manage and precisely control multiple motor components within the microscope, such as objective change, focusing, condenser switching, fluorescent module change.

Multidimensional Viewing

It can memorize custom observation modes and support X, Y, Z, λ, T scanning function combinations. The system is built-in various flexible shooting modes, including multi-channel fluorescence imaging, time series scanning, multi-position data acquisition, Z-stack and panoramic stitching. These five modes can be combined according to users' actual needs and adapt to various complex experimental application scenarios.

Devonvolution

2D images can be de-blurred. Multiple deconvolution operations can be applied to eliminate the shot noise component in confocal images. 3D deconvolution technique can also be used for multi-dimensional images.

High Performance Confocal Platform

The NIB1000 inverted microscope provides a powerful and flexible imaging solution for the NCF1000 confocal system, creating a robust and scalable microscopic imaging infrastructure. The wide 25 mm field of view provides ideal observation conditions for large samples and high-throughput experimental research. Integrating various microscopy technologies such as brightfield, fluorescence, DIC, phase contrast, the system allows users to freely choose single- or double-layer optical path configuration scheme according to the experimental content, enabling them to achieve the best imaging effect. The Adaptive Focus System (AFS) ensures constant accurate focal plane positioning during observation, ensuring stable and continuous clear cell dynamic behavior recordings.

High-speed Motorized Control

Live Cell Imaging System

Designed for live cell imaging, it accurately regulates the temperature of the microscope slide to maintain constant temperature, humidity and CO2, providing an ideal culture environment for long-term experiments.

Adaptive Focus System (AFM)

NIB1000 uses an independent focusing design to minimize the influence of other mechanical components on the Z-axis. The newly designed Adaptive Focus System (AFS) intelligently eliminates focus deviation. No matter the large NA value of high-magnification objective or the use of super-resolution, confocal, TIRF and other imaging technologies, it always delivers a clear and sharp image.

High Specification LED Fluorescent Lighting System

LED4 achieves up to 4 channels of LED illumination, excitation energy concentration, large brightness, to meet the needs of daily experimental fluorescence imaging. It can be used continuously with power on, long life, no need to replace the bulb. Reduces photobleaching and phototoxicity, friendly to living cell samples

 

Interactive Operation

The front panel of NIB1000 is designed as a touch screen, which greatly improves the ease of use and functional expandability of human-computer interaction. The traditional microscope handles and buttons are retained on the left and right sides. With this design, it can be easily controlled even in dark laboratory environments. Researchers can focus on the essence of their experiments without complicated operations and experience efficient, trouble-free microscopic observation.

Wide aperture optical system and fluorescent illumination

Equipped with large aperture tube lens, significantly increase the amount of light, combined with wide-field CMOS sensor, it is easy to achieve bright field and fluorescence imaging up to FOV25mm. Designed for FOV25mm wide field of view, the fluorescent illuminator device is equipped with high-power LED light to provide a wide high-transmittance illumination spectrum including ultraviolet spectrum, while the matched large-diameter fluorescent filters provide fluorescent images with high signal-to-noise ratio.

The 5.6-inch touch screen on the front of the fuselage can control the objective lens, double/single layer fluorescent filter turret, condenser light intensity, motorized stage speed, motorized Z-axis speed, beam splitter, ESC output, FN key, objective focus and other electrical components by touch. It displays the objective magnification, illumination brightness, fluorescent channel, output port, XYZ position and speed and other components in real time.